Case study: the role of mechanistic network models in systems toxicology
J Hoeng, M Talikka, F Martin, A Sewer, X Yang… - Drug Discovery …, 2014 - Elsevier
Highlights•Biological network models enable a mechanistic understanding of high-
throughput data.•Network response can be quantified for the impact of a given stimulus.•The
systems-wide biological impact can be computed using multiple networks.•Network-based
approach enables biomarker identification in response to exposure.Twenty first century
systems toxicology approaches enable the discovery of biological pathways affected in
response to active substances. Here, we briefly summarize current network approaches that …
throughput data.•Network response can be quantified for the impact of a given stimulus.•The
systems-wide biological impact can be computed using multiple networks.•Network-based
approach enables biomarker identification in response to exposure.Twenty first century
systems toxicology approaches enable the discovery of biological pathways affected in
response to active substances. Here, we briefly summarize current network approaches that …
